Other Events Observed in the Clinical Development of IMITREX: The following adverse events occurred in clinical trials with IMITREX Tablets and IMITREX Nasal Spray. Because the reports include events observed in open and uncontrolled studies, the role of IMITREX in their causation cannot be reliably determined. All reported events are included except those already listed, those too general to be informative, and those not reasonably associated with the use of the drug. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine. The sum of the percentages cited is greater than 100% because patients may experience more than 1 type of adverse event. Only events that occurred at a frequency of 1% or more in groups treated with IMITREX Injection and were at least as frequent in the placebo groups are included. get pyridium prescription
Store Imitrex tablets between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F 30 degrees C. Do not store in the bathroom. Keep Imitrex tablets in the case provided. Throw away expired medicine as directed by your doctor the expiration date is printed on the treatment pack. Keep Imitrex tablets out of the reach of children and away from pets. CAD, female with surgical or physiological menopause, or male over 40 years of age unless a cardiovascular evaluation provides satisfactory clinical evidence that the patient is reasonably free of coronary artery and ischemic myocardial disease or other significant underlying cardiovascular disease. The sensitivity of cardiac diagnostic procedures to detect cardiovascular disease or predisposition to coronary artery vasospasm is modest, at best.
B” to help you keep track of your doses. An extra patient leaflet is available with Imitrex spray. Talk to your pharmacist if you have questions about this information. Table 2 below, onset of relief began as early as 10 minutes following a 6-mg IMITREX Injection. Smaller doses of sumatriptan may also prove effective, although the proportion of patients obtaining adequate relief is decreased and the latency to that relief is greater.
IMITREX Injection, call your doctor immediately. Other News "AAN meeting: sumatriptan linked to life-threatening intestinal condition. Table 3, onset of relief began as early as 10 minutes following a 6-mg Imitrex Injection. Lower doses of Imitrex Injection may also prove effective, although the proportion of patients obtaining adequate relief was decreased and the latency to that relief is greater with lower doses. Discuss the risks and benefits with your doctor. You don't want to take your medicine too often, since it may stop working or cause more intense and more frequent "rebound headaches.
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Put the Pen in the open Cartridge Pack. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. One report has suggested that "throat tightness" and chest pain associated with sumatriptan may sometimes be attributable to changes in esophageal motility. This may not be a complete list of all interactions that may occur. Ask your health care provider if Imitrex spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Overdose in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation. You may begin to sweat a lot, or light may bother you. Sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw commonly occur after treatment with Imitrex Injection and are usually non-cardiac in origin. However, perform a cardiac evaluation if these patients are at high cardiac risk. Respiratory: Infrequent was dyspnea. Rare were influenza, diseases of the lower respiratory tract, and hiccoughs. This medicine may cause stomach bleeding. If you use too much IMITREX, call your healthcare provider or go to the nearest hospital emergency room right away. After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. Do not take more than 200 mg of sumatriptan oral tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets. Triptans work best when they are taken as soon as the headache starts. But they can still reduce headache pain and other symptoms when taken after the attack has begun.
Trials 1, 2, and 3 following administration of Imitrex Tablets compared with placebo. Ask your doctor or pharmacist about using this product safely. IMITREX may cause serious side effects. The product samples shown here have been supplied by the manufacturer. While every effort has been made to assure accurate reproduction, please remember that any visual identification should be considered preliminary. In cases of poisoning or suspected overdosage, the drug's identity should be verified by chemical analysis. To remember a person's name, repeat it several times after being introduced. Clinical trials of Imitrex Injection did not include sufficient numbers of patients 65 years of age and older to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. Patients who are advised to self-administer IMITREX Injection in medically unsupervised situations should receive instruction on the proper use of the product from the physician or other suitably qualified health care professional prior to doing so for the first time. IMITREX STAT dose System NDC 0173-0739-02. Swelling in the feet, lower legs, or fingers. If your symptoms are only partly relieved or your headache returns, 2 hours after the injection you may switch to sumatriptan taken by mouth instead of using a second injection. After the initial injection you may take sumatriptan by mouth every 2 hours if needed to a maximum of 100 milligrams of tablets in a 24-hour period. Overuse of drugs to treat sudden migraine attacks can sometimes lead to worsening of headache medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches. Consult your doctor or if you have questions about the ingredients in your brand. Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Avoid taking MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. For the treatment of cluster headache, the efficacy of lower doses has not been established. USP in Water for Injection, USP. xeloda
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. If not, I eat something and take the rest of the pill about an hour later. Product Information. Imitrex injection sumatriptan. Keep IMITREX and all medicines out of the reach of children. Biofeedback and relaxation. Biofeedback helps you control how muscle groups react to stress. This may help prevent or relieve tension headaches. Imitrex spray is not approved for use in CHILDREN younger than 18 years old. Talk with the doctor. Hepatic Impairment: The effect of hepatic disease on the pharmacokinetics of subcutaneously and orally administered sumatriptan has been evaluated. There were no statistically significant differences in the pharmacokinetics of subcutaneously administered sumatriptan in hepatically impaired patients compared to healthy controls. However, the liver plays an important role in the presystemic clearance of orally administered sumatriptan. Accordingly, the bioavailability of sumatriptan following oral administration may be markedly increased in patients with liver disease. IMITREX. Such reactions can be life threatening or fatal. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens. Imitrex Injection is contraindicated in patients with a history of hypersensitivity reaction to IMITREX. Heart attack and other heart problems. Heart problems may lead to death. Pregnancy Registry: To monitor fetal outcomes of pregnant women exposed to IMITREX, GlaxoSmithKline maintains a Sumatriptan Pregnancy Registry. Physicians are encouraged to register patients by calling 800 336-2176. Our Imitrex Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Your dosage is based on your medical condition and response to therapy. Tell your doctor if your condition does not improve or worsens. vcet.info betapace
General information about the safe and effective use of Imitrex. Have you had, or do you have, epilepsy or seizures? Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. The pharmacokinetics of sumatriptan in patients with severe hepatic impairment has not been studied. Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications like dihydroergotamine or methysergide and Imitrex Injection within 24 hours of each other is contraindicated. To use Imitrex spray, remove the nasal spray unit from the plastic pack. Imitrex Injection. Such reactions can be life threatening or fatal. order caverta vs
Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Discontinue Imitrex Injection if these disturbances occur. Imitrex Injection is contraindicated in patients with Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders. The plot was constructed with data from patients who either experienced relief or did not require request rescue medication within a period of 2 hours following treatment. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 sumatriptan-treated headaches. You may have to try different drugs or doses. If you have already tried several medicines, your doctor may order tests such as an or to find out if a health problem is causing your headaches. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody diarrhea; burning or aching in your feet or toes; burning, numbness, or tingling; constipation; diarrhea; fainting; feeling of heaviness or tightness in your leg muscles; fever; hearing problems; leg cramps; seizures; severe or persistent headache, dizziness, nausea, or vomiting; severe stomach pain; very cold or blue fingers or toes; vision changes or loss of vision; weight loss; wheezing. Use Imitrex tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. Hepatic: Elevated liver function tests. IMITREX Injection 1 hour after the initial injection. Read the Patient Information Leaflet available from your pharmacist before you start using sumatriptan and each time you get a refill. Ask your doctor or pharmacist if you have any questions. IMITREX Injection is intended to relieve your migraine or cluster headache, but not to prevent or reduce the number of attacks you experience. Use IMITREX Injection only to treat an actual migraine or cluster headache attack. The incidence of adverse events in controlled clinical trials was not affected by gender or age of the patients. There were insufficient data to assess the impact of race on the incidence of adverse events. Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Pack for the 6-mg strength is blue as shown. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see Drug Interactions section. Imitrex spray is to be used only by the patient for whom it is prescribed. Do not share it with other people. AUC corresponding to a 40% increase in elimination half-life. Sumatriptan injection is not approved for use by anyone younger than 18 years old. store carbidopa buller
Special Populations: Renal Impairment: The effect of renal impairment on the pharmacokinetics of sumatriptan has not been examined, but little clinical effect would be expected as sumatriptan is largely metabolized to an inactive substance. If your symptoms do not improve or if they become worse, check with your doctor. What is the most important information I should know about Imitrex? Then close the lid. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody diarrhea; burning or aching in your feet or toes; burning, numbness, or tingling; constipation; diarrhea; fainting; feeling or heaviness or tightness in your leg muscles; fever; hearing problems; leg cramps; seizures; severe or persistent headache, dizziness, nausea, or vomiting; severe stomach pain; very cold or blue fingers or toes; vision changes or loss of vision; weight loss; wheezing. After using sumatriptan nasal spray, you must wait two 2 hours before using a second spray. Do not use more than 40 mg of sumatriptan nasal spray in 24 hours. What happens if I overdose? Do not touch the Blue Button until you have pressed the Pen firmly against your skin to give a dose. Concomitant Drug Use: In patients taking MAO-A inhibitors, sumatriptan plasma levels attained after treatment with recommended doses are nearly double those obtained under other conditions. Accordingly, the coadministration of sumatriptan and an MAO-A inhibitor is not generally recommended. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Rare were herpes, swelling of face, sweating, and peeling of skin. purchase lisinopril mastercard otc
Imitrex is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. Treatment with Imitrex Injection may cause somnolence and dizziness; instruct patients to evaluate their ability to perform complex tasks after administration of Imitrex Injection. Heart Rate: Transient increases in blood pressure observed in some patients in clinical studies carried out during sumatriptan's development as a treatment for migraine were not accompanied by any clinically significant changes in heart rate. Nursing Mothers: Sumatriptan is excreted in human breast milk. Therefore, caution should be exercised when considering the administration of IMITREX Injection to a nursing woman. Therefore, do not use this medication more often or for longer than prescribed. Each tablet also contains the inactive ingredients croscarmellose sodium, dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, and sodium bicarbonate. Each 100-mg tablet also contains hypromellose, iron oxide, titanium dioxide, and triacetin. Break the task down into simple steps. You may find it helpful to give the person written instructions. Read the Patient Information Leaflet available from your before you start using and each time you get a refill. Ask your doctor or pharmacist if you have any questions. This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine. Dachs R, Vitillo J "Angioedema associated with sumatriptan administration. The trials did not establish the efficacy of IMITREX Nasal Spray compared with placebo in the treatment of migraine in pediatric patients. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. Willett F, Curzen N, Adams J, Armitage M "Coronary vasospasm induced by subcutaneous sumatriptan. An autoinjection system is available for self-administration. The trials did not establish the efficacy of Imitrex Nasal Spray compared with placebo in the treatment of migraine in adolescents. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. tenormin
Headache relief, as evidenced by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70% of the patients within 1 hour of a single 6-mg subcutaneous dose of IMITREX Injection. Headache relief was achieved in approximately 82% of patients within 2 hours, and 65% of all patients were pain free within 2 hours. Do not touch the needle. Throw away the seal. Open the lid over the Syringe Cartridge. Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients treated with 5-HT1 agonists, including patients without a history of hypertension. Monitor blood pressure in patients treated with Imitrex. Imitrex Tablets are contraindicated in patients with uncontrolled hypertension. It's a good idea to avoid or replacement products for several hours after taking these medicines. or other forms of nicotine can increase the side effects of ergotamines. Men get them more than women do. You usually start getting them before you're age 30. Cluster headaches may disappear completely go into remission for months or years, but they can come back without any warning. Autoinjector Pen: Each pack contains a Patient Information and Instructions for Use leaflet. Pen as shown in Figure B before you load a new Syringe Cartridge. Sumatriptan is excreted in human milk following subcutaneous administration. Infant exposure to sumatriptan can be minimized by avoiding breastfeeding for 12 hours after treatment with Imitrex Injection. Some medicines can harm your baby. When you inject the dose, make sure the Pen stays in contact with your skin during the injection. It is important to hold the Pen against the skin for at least 5 seconds. Choose and Prepare the Injection Site.
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IMITREX may cause serious side effects. See “What is the most important information I should know about IMITREX? Store easy-to-lose items in the same place each time after you use them. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. serevent
Pen ready for the next use. Treatment should be started at the first sign of a migraine headache, or associated symptoms such as nausea, vomiting, or photophobia; this drug should not be used for migraine prophylaxis. You can take it as a pill or as a suppository if nausea or vomiting stops you from keeping anything down. Another form of ergotamine, called DHE 45 also treats them. You can get it as an injection or as a nasal spray. Pale or blue-colored hands or feet. order cheapest metronidazole store europe
Imitrex, IMITREX STATdose Pen, and IMITREX STATdose System are registered trademarks of the GSK group of companies. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. Sumatriptan is used to treat migraines.
In the controlled clinical trials assessing the efficacy of Imitrex Injection as a treatment for cluster headache Studies 4 and 5 no new significant adverse reactions were detected that had not already been identified in trials of IMITREX in patients with migraine. In some cases, your doctor may prescribe stronger medicine if over-the-counter drugs don't stop your headaches. Pedialyte and drinking it. I also recommend asking your doctor about the Compazine. You should also understand WHY your body is reacting with the diarrhea. There is obviously a connection between our digestive systems and the intense headaches. I just worry that I've opened up Pandora's box in my body and will now have to deal with migraine headaches in the future.